janex 1 Search Results


janex 1  (MedChemExpress)
91
MedChemExpress janex 1
Janex 1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/janex 1/product/MedChemExpress
Average 91 stars, based on 1 article reviews
janex 1 - by Bioz Stars, 2026-02
91/100 stars
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inhibitor janex  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology inhibitor janex
Inhibitor Janex, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
inhibitor janex - by Bioz Stars, 2026-02
93/100 stars
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jak3 inhibitor janex 1  (Selleck Chemicals)
93
Selleck Chemicals jak3 inhibitor janex 1
PIK3CD was positively regulated by <t>JAK3/STAT5</t> signaling. (A) Heat maps of top 50 genes positively correlated with PIK3CD expression in STAD cohort of TCGA by LinkedOmics online tools. STAD, stomach adenocarcinoma. (B) The expression of PIK3CD was positively associated with JAK3, STAT5A and STAT5B in TCGA by Pearson correlation analysis. (C) The potential binding site of STAT5 in the promoter of PIK3CD. The four red nucleotides were mutated from wild‐type binding sites for construction of dual luciferase reporter plasmid (MUT). (D) The relative activities of PIK3CD promoter were examined by dual luciferase reporter kit in GC cells with STAT5A overexpression. * p < 0.05, ** p < 0.01. (E) The protein expression was tested by western blotting upon STAT5A overexpression in MGC803 and AGS cells. (F) Cells were treated with human IL‐2, JANEX‐1 and STAT5 inhibitor (SH‐4‐54) as indicated concentrations. PIK3CD expression was examined by western blot analysis. JANEX‐1, JAK3 inhibitor.
Jak3 Inhibitor Janex 1, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
jak3 inhibitor janex 1 - by Bioz Stars, 2026-02
93/100 stars
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whi-p131 (4-[(6,7-dimethoxy-4-quinazolinyl) amino]-phenol; janex-1  (Cayman Chemical)
90
Cayman Chemical whi-p131 (4-[(6,7-dimethoxy-4-quinazolinyl) amino]-phenol; janex-1
PIK3CD was positively regulated by <t>JAK3/STAT5</t> signaling. (A) Heat maps of top 50 genes positively correlated with PIK3CD expression in STAD cohort of TCGA by LinkedOmics online tools. STAD, stomach adenocarcinoma. (B) The expression of PIK3CD was positively associated with JAK3, STAT5A and STAT5B in TCGA by Pearson correlation analysis. (C) The potential binding site of STAT5 in the promoter of PIK3CD. The four red nucleotides were mutated from wild‐type binding sites for construction of dual luciferase reporter plasmid (MUT). (D) The relative activities of PIK3CD promoter were examined by dual luciferase reporter kit in GC cells with STAT5A overexpression. * p < 0.05, ** p < 0.01. (E) The protein expression was tested by western blotting upon STAT5A overexpression in MGC803 and AGS cells. (F) Cells were treated with human IL‐2, JANEX‐1 and STAT5 inhibitor (SH‐4‐54) as indicated concentrations. PIK3CD expression was examined by western blot analysis. JANEX‐1, JAK3 inhibitor.
Whi P131 (4 [(6,7 Dimethoxy 4 Quinazolinyl) Amino] Phenol; Janex 1, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/whi-p131 (4-[(6,7-dimethoxy-4-quinazolinyl) amino]-phenol; janex-1/product/Cayman Chemical
Average 90 stars, based on 1 article reviews
whi-p131 (4-[(6,7-dimethoxy-4-quinazolinyl) amino]-phenol; janex-1 - by Bioz Stars, 2026-02
90/100 stars
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jak3 inhibitor janex-1  (Cayman Chemical)
90
Cayman Chemical jak3 inhibitor janex-1
PIK3CD was positively regulated by <t>JAK3/STAT5</t> signaling. (A) Heat maps of top 50 genes positively correlated with PIK3CD expression in STAD cohort of TCGA by LinkedOmics online tools. STAD, stomach adenocarcinoma. (B) The expression of PIK3CD was positively associated with JAK3, STAT5A and STAT5B in TCGA by Pearson correlation analysis. (C) The potential binding site of STAT5 in the promoter of PIK3CD. The four red nucleotides were mutated from wild‐type binding sites for construction of dual luciferase reporter plasmid (MUT). (D) The relative activities of PIK3CD promoter were examined by dual luciferase reporter kit in GC cells with STAT5A overexpression. * p < 0.05, ** p < 0.01. (E) The protein expression was tested by western blotting upon STAT5A overexpression in MGC803 and AGS cells. (F) Cells were treated with human IL‐2, JANEX‐1 and STAT5 inhibitor (SH‐4‐54) as indicated concentrations. PIK3CD expression was examined by western blot analysis. JANEX‐1, JAK3 inhibitor.
Jak3 Inhibitor Janex 1, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jak3 inhibitor janex-1/product/Cayman Chemical
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janex-1-m  (GraphPad Software Inc)
90
GraphPad Software Inc janex-1-m
PIK3CD was positively regulated by <t>JAK3/STAT5</t> signaling. (A) Heat maps of top 50 genes positively correlated with PIK3CD expression in STAD cohort of TCGA by LinkedOmics online tools. STAD, stomach adenocarcinoma. (B) The expression of PIK3CD was positively associated with JAK3, STAT5A and STAT5B in TCGA by Pearson correlation analysis. (C) The potential binding site of STAT5 in the promoter of PIK3CD. The four red nucleotides were mutated from wild‐type binding sites for construction of dual luciferase reporter plasmid (MUT). (D) The relative activities of PIK3CD promoter were examined by dual luciferase reporter kit in GC cells with STAT5A overexpression. * p < 0.05, ** p < 0.01. (E) The protein expression was tested by western blotting upon STAT5A overexpression in MGC803 and AGS cells. (F) Cells were treated with human IL‐2, JANEX‐1 and STAT5 inhibitor (SH‐4‐54) as indicated concentrations. PIK3CD expression was examined by western blot analysis. JANEX‐1, JAK3 inhibitor.
Janex 1 M, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/janex-1-m/product/GraphPad Software Inc
Average 90 stars, based on 1 article reviews
janex-1-m - by Bioz Stars, 2026-02
90/100 stars
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janex-1 treatment nod mice  (Taconic Biosciences)
90
Taconic Biosciences janex-1 treatment nod mice
PIK3CD was positively regulated by <t>JAK3/STAT5</t> signaling. (A) Heat maps of top 50 genes positively correlated with PIK3CD expression in STAD cohort of TCGA by LinkedOmics online tools. STAD, stomach adenocarcinoma. (B) The expression of PIK3CD was positively associated with JAK3, STAT5A and STAT5B in TCGA by Pearson correlation analysis. (C) The potential binding site of STAT5 in the promoter of PIK3CD. The four red nucleotides were mutated from wild‐type binding sites for construction of dual luciferase reporter plasmid (MUT). (D) The relative activities of PIK3CD promoter were examined by dual luciferase reporter kit in GC cells with STAT5A overexpression. * p < 0.05, ** p < 0.01. (E) The protein expression was tested by western blotting upon STAT5A overexpression in MGC803 and AGS cells. (F) Cells were treated with human IL‐2, JANEX‐1 and STAT5 inhibitor (SH‐4‐54) as indicated concentrations. PIK3CD expression was examined by western blot analysis. JANEX‐1, JAK3 inhibitor.
Janex 1 Treatment Nod Mice, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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Image Search Results


PIK3CD was positively regulated by JAK3/STAT5 signaling. (A) Heat maps of top 50 genes positively correlated with PIK3CD expression in STAD cohort of TCGA by LinkedOmics online tools. STAD, stomach adenocarcinoma. (B) The expression of PIK3CD was positively associated with JAK3, STAT5A and STAT5B in TCGA by Pearson correlation analysis. (C) The potential binding site of STAT5 in the promoter of PIK3CD. The four red nucleotides were mutated from wild‐type binding sites for construction of dual luciferase reporter plasmid (MUT). (D) The relative activities of PIK3CD promoter were examined by dual luciferase reporter kit in GC cells with STAT5A overexpression. * p < 0.05, ** p < 0.01. (E) The protein expression was tested by western blotting upon STAT5A overexpression in MGC803 and AGS cells. (F) Cells were treated with human IL‐2, JANEX‐1 and STAT5 inhibitor (SH‐4‐54) as indicated concentrations. PIK3CD expression was examined by western blot analysis. JANEX‐1, JAK3 inhibitor.

Journal: Journal of Cell Communication and Signaling

Article Title: JAK3/STAT5 signaling‐triggered upregulation of PIK3CD contributes to gastric carcinoma development

doi: 10.1002/ccs3.12017

Figure Lengend Snippet: PIK3CD was positively regulated by JAK3/STAT5 signaling. (A) Heat maps of top 50 genes positively correlated with PIK3CD expression in STAD cohort of TCGA by LinkedOmics online tools. STAD, stomach adenocarcinoma. (B) The expression of PIK3CD was positively associated with JAK3, STAT5A and STAT5B in TCGA by Pearson correlation analysis. (C) The potential binding site of STAT5 in the promoter of PIK3CD. The four red nucleotides were mutated from wild‐type binding sites for construction of dual luciferase reporter plasmid (MUT). (D) The relative activities of PIK3CD promoter were examined by dual luciferase reporter kit in GC cells with STAT5A overexpression. * p < 0.05, ** p < 0.01. (E) The protein expression was tested by western blotting upon STAT5A overexpression in MGC803 and AGS cells. (F) Cells were treated with human IL‐2, JANEX‐1 and STAT5 inhibitor (SH‐4‐54) as indicated concentrations. PIK3CD expression was examined by western blot analysis. JANEX‐1, JAK3 inhibitor.

Article Snippet: PI3Kδ inhibitors, including Acalisib (#S5818), compound 7n (#S8693) and Idelalisib (#S2226), STAT3/STAT5 inhibitor SH‐4‐54 (#S7337), STAT3 inhibitor BP‐1‐102 (#S7769), and JAK3 inhibitor JANEX‐1 (#S5903) were purchased from Selleck Chemicals.

Techniques: Expressing, Binding Assay, Luciferase, Plasmid Preparation, Over Expression, Western Blot

The correlations between PI3K subunits, JAK3 and immune cell infiltration in GC. (A) PIK3CA and immune cell infiltration. The correlation analysis between each gene with immune cell infiltration was performed via TIMER algorithm. (B) PIK3CB and immune cell infiltration. The correlation analysis between each gene with immune cell infiltration was performed via TIMER algorithm. (C) PIK3CD and immune cell infiltration. The correlation analysis between each gene with immune cell infiltration was performed via TIMER algorithm. (D) JAK3 and immune cell infiltration. The correlation analysis between each gene with immune cell infiltration was performed via TIMER algorithm. (E) Pro‐inflammatory lymphocyte and LPS had significant impact on PIK3CD expression, but not for PIK3CA and PIK3CB. (F) The effect of overexpression of STAT5 on protein expression of PIK3CA, PIK3CB and PIK3CD. (G) The effect of JANEX‐1 and STAT5 inhibitor (SH‐45‐4) on protein expression of PIK3CA, PIK3CB and PIK3CD. GC, gastric cancer; JANEX‐1, JAK3 inhibitor; LPS, lipopolysaccharide.

Journal: Journal of Cell Communication and Signaling

Article Title: JAK3/STAT5 signaling‐triggered upregulation of PIK3CD contributes to gastric carcinoma development

doi: 10.1002/ccs3.12017

Figure Lengend Snippet: The correlations between PI3K subunits, JAK3 and immune cell infiltration in GC. (A) PIK3CA and immune cell infiltration. The correlation analysis between each gene with immune cell infiltration was performed via TIMER algorithm. (B) PIK3CB and immune cell infiltration. The correlation analysis between each gene with immune cell infiltration was performed via TIMER algorithm. (C) PIK3CD and immune cell infiltration. The correlation analysis between each gene with immune cell infiltration was performed via TIMER algorithm. (D) JAK3 and immune cell infiltration. The correlation analysis between each gene with immune cell infiltration was performed via TIMER algorithm. (E) Pro‐inflammatory lymphocyte and LPS had significant impact on PIK3CD expression, but not for PIK3CA and PIK3CB. (F) The effect of overexpression of STAT5 on protein expression of PIK3CA, PIK3CB and PIK3CD. (G) The effect of JANEX‐1 and STAT5 inhibitor (SH‐45‐4) on protein expression of PIK3CA, PIK3CB and PIK3CD. GC, gastric cancer; JANEX‐1, JAK3 inhibitor; LPS, lipopolysaccharide.

Article Snippet: PI3Kδ inhibitors, including Acalisib (#S5818), compound 7n (#S8693) and Idelalisib (#S2226), STAT3/STAT5 inhibitor SH‐4‐54 (#S7337), STAT3 inhibitor BP‐1‐102 (#S7769), and JAK3 inhibitor JANEX‐1 (#S5903) were purchased from Selleck Chemicals.

Techniques: Expressing, Over Expression